PTK2B

PTK2B
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	2LK4, 3CC6, 3ET7, 3FZO, 3FZP, 3FZR, 3FZS, 3FZT, 3GM1, 3GM2, 3GM3, 3H3C, 3U3F, 4EKU, 4H1J, 4H1M, 4R32, 4XEK, 4XEF, 4XEV
المعرفات
الأسماء المستعارة	PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK, protein tyrosine kinase 2 beta
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 601212 MGI: MGI:104908 HomoloGene: 23001 GeneCards: 2185
علم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0032403 macromolecular complex binding; • kinase activity; • receptor binding; • ATP binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • نشاط انتقالي; • ‏GO:0001948 ربط بروتيني; • nucleotide binding; • 3-phosphoinositide-dependent protein kinase binding; • NMDA glutamate receptor activity; • signal transducer activity; • calmodulin-dependent protein kinase activity; • enzyme binding; • protein tyrosine kinase activity; • ubiquitin protein ligase binding; • protein C-terminus binding;
المكونات الخلوية	• غشاء; • focal adhesion; • extrinsic component of cytoplasmic side of plasma membrane; • NMDA selective glutamate receptor complex; • perinuclear region of cytoplasm; • هيكل خلوي; • نواة; • إسقاط خلية; • membrane raft; • lamellipodium; • apical dendrite; • مخروط النمو; • غشاء خلوي; • محوار; • neuronal cell body; • قشرة الخلية; • cell body; • ‏GO:0097483، ‏GO:0097481 كثافة بعد المشبكي; • موصل خلوي; • تغصن; • عصارة خلوية; • سيتوبلازم; • dendritic spine; • postsynapse; • glutamatergic synapse;
العمليات الحيوية	• negative regulation of neuron apoptotic process; • cellular response to retinoic acid; • adaptive immune response; • positive regulation of actin filament polymerization; • tumor necrosis factor-mediated signaling pathway; • positive regulation of JNK cascade; • regulation of angiogenesis; • marginal zone B cell differentiation; • negative regulation of muscle cell apoptotic process; • positive regulation of translation; • stress fiber assembly; • negative regulation of ossification; • protein phosphorylation; • سبيل إشارات مستقبلات سطح الخلية; • vascular endothelial growth factor receptor signaling pathway; • regulation of cell adhesion; • positive regulation of reactive oxygen species metabolic process; • توليد الأوعية; • positive regulation of ERK1 and ERK2 cascade; • long term synaptic depression; • positive regulation of excitatory postsynaptic potential; • regulation of cGMP-mediated signaling; • response to ethanol; • neuron projection development; • negative regulation of cell proliferation; • response to cocaine; • استماتة; • regulation of actin cytoskeleton reorganization; • positive regulation of cellular protein metabolic process; • epidermal growth factor receptor signaling pathway; • actin filament organization; • response to reactive oxygen species; • chemokine-mediated signaling pathway; • response to mechanical stimulus; • signal complex assembly; • ارتشاف عظمي; • response to lithium ion; • response to osmotic stress; • positive regulation of cell growth; • positive regulation of nitric-oxide synthase activity; • positive regulation of synaptic transmission, glutamatergic; • ionotropic glutamate receptor signaling pathway; • response to organonitrogen compound; • positive regulation of DNA biosynthetic process; • positive regulation of peptidyl-tyrosine phosphorylation; • autophosphorylation; • مناعة فطرية; • negative regulation of myeloid cell differentiation; • response to immobilization stress; • تمايز خلوي; • فسفرة; • positive regulation of cell-matrix adhesion; • positive regulation of JUN kinase activity; • immune system process; • regulation of release of sequestered calcium ion into cytosol; • negative regulation of apoptotic process; • sprouting angiogenesis; • regulation of inositol trisphosphate biosynthetic process; • response to glucose; • cellular response to fluid shear stress; • positive regulation of angiogenesis; • response to calcium ion; • regulation of NMDA receptor activity; • cellular defense response; • oocyte maturation; • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; • negative regulation of potassium ion transport; • regulation of cell shape; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • positive regulation of B cell chemotaxis; • response to hormone; • response to cAMP; • regulation of nitric oxide biosynthetic process; • regulation of establishment of cell polarity; • response to hydrogen peroxide; • regulation of macrophage chemotaxis; • positive regulation of protein kinase activity; • regulation of leukocyte chemotaxis; • negative regulation of bone mineralization; • regulation of cell migration; • response to hypoxia; • blood vessel endothelial cell migration; • ‏GO:0032861، ‏GO:0032862، ‏GO:0032856 activation of GTPase activity; • positive regulation of cell migration; • regulation of bone mineralization; • positive regulation of cytosolic calcium ion concentration; • positive regulation of nitric oxide biosynthetic process; • response to stress; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of endothelial cell migration; • focal adhesion assembly; • regulation of cell proliferation; • regulation of calcium-mediated signaling; • ضبط زيادي للتكاثر الخلوي; • positive regulation of neuron projection development; • glial cell proliferation; • activation of Janus kinase activity; • peptidyl-tyrosine phosphorylation; • regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; • response to drug; • توصيل الإشارة; • long-term synaptic potentiation; • التصاق الخلايا; • interleukin-7-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • regulation of synaptic plasticity; • macromolecular complex assembly;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q14289
	Q9QVP9
	‏NM_004103، ‏NM_173174، ‏NM_173175، ‏NM_173176، ‏XM_005273447، ‏XM_005273448، ‏XM_011544441، ‏XM_017013214، ‏XM_017013215، ‏XM_017013216 XM_011544442، ‏NM_004103، ‏NM_173174، ‏NM_173175، ‏NM_173176، ‏XM_005273447، ‏XM_005273448، ‏XM_011544441، ‏XM_017013214، ‏XM_017013215، ‏XM_017013216
	‏NM_001162366، ‏NM_172498، ‏XM_017315926، ‏XM_017315927، ‏XM_017315928، ‏XM_017315929، ‏XM_017315930، ‏NM_001360233 NM_001162365، ‏NM_001162366، ‏NM_172498، ‏XM_017315926، ‏XM_017315927، ‏XM_017315928، ‏XM_017315929، ‏XM_017315930، ‏NM_001360233
	‏NP_775266، ‏NP_775267، ‏NP_775268، ‏XP_005273504، ‏XP_005273505، ‏XP_011542743، ‏XP_011542744، ‏XP_016868703، ‏XP_016868704، ‏XP_016868705 NP_004094، ‏NP_775266، ‏NP_775267، ‏NP_775268، ‏XP_005273504، ‏XP_005273505، ‏XP_011542743، ‏XP_011542744، ‏XP_016868703، ‏XP_016868704، ‏XP_016868705
	‏NP_001155838، ‏NP_766086، ‏XP_017171415، ‏XP_017171416، ‏XP_017171417، ‏XP_017171418، ‏XP_017171419، ‏NP_001347162 NP_001155837، ‏NP_001155838، ‏NP_766086، ‏XP_017171415، ‏XP_017171416، ‏XP_017171417، ‏XP_017171418، ‏XP_017171419، ‏NP_001347162
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

PTK2B (اختصارًا لاسم Protein tyrosine kinase 2 beta) هو بروتين في البشر يُشفر عبر جين PTK2B.[1][2]

المراجع

Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J (September 1995). "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions". Nature. 376 (6543): 737–45. doi:10.1038/376737a0. PMID 7544443. الوسيط |CitationClass= تم تجاهله (مساعدة)
Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S, Pasztor LM, White RA, Groopman JE (1995). "Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain". J. Biol. Chem. 270 (46): 27742–51. doi:10.1074/jbc.270.46.27742. PMID 7499242. الوسيط |CitationClass= تم تجاهله (مساعدة)

بوابة علم الأحياء
بوابة علم الأحياء الخلوي والجزيئي

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[pmid7544443-1] Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J (September 1995). "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions". Nature. 376 (6543): 737–45. doi:10.1038/376737a0. PMID 7544443. الوسيط |CitationClass= تم تجاهله (مساعدة)

[pmid7499242-2] Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S, Pasztor LM, White RA, Groopman JE (1995). "Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain". J. Biol. Chem. 270 (46): 27742–51. doi:10.1074/jbc.270.46.27742. PMID 7499242. الوسيط |CitationClass= تم تجاهله (مساعدة)