PDGFB

PDGFB
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1PDG, 3MJG, 4HQU, 4HQX, 4QCI
المعرفات
الأسماء المستعارة	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 190040 MGI: MGI:97528 HomoloGene: 74303 GeneCards: 5155
علم الوجود الجيني
الوظيفة الجزيئية	• protein homodimerization activity; • protein heterodimerization activity; • chemoattractant activity; • platelet-derived growth factor receptor binding; • platelet-derived growth factor binding; • superoxide-generating NADPH oxidase activator activity; • growth factor activity; • identical protein binding; • collagen binding; • ‏GO:0001948 ربط بروتيني; • Ras guanyl-nucleotide exchange factor activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
المكونات الخلوية	• platelet alpha granule lumen; • سيتوبلازم; • منطقة خارج الخلية; • Golgi membrane; • basolateral plasma membrane; • cell surface; • endoplasmic reticulum lumen; • غشاء; • نسيج خارج الخلية; • خارج خلوي; • تجويف غولجي; • collagen-containing extracellular matrix;
العمليات الحيوية	• activation of protein kinase B activity; • positive regulation of DNA biosynthetic process; • positive regulation of chemotaxis; • cellular response to growth factor stimulus; • positive regulation of protein tyrosine kinase activity; • peptidyl-tyrosine phosphorylation; • positive regulation of cell division; • heart development; • positive regulation of glomerular filtration; • positive regulation of mitotic nuclear division; • positive regulation of MAP kinase activity; • positive regulation of metanephric mesenchymal cell migration; • positive regulation of hyaluronan biosynthetic process; • MAPK cascade; • protein phosphorylation; • positive regulation of glomerular mesangial cell proliferation; • cellular response to mycophenolic acid; • positive regulation of fibroblast proliferation; • activation of protein kinase activity; • نمو متعدد الخلايا; • positive regulation of protein autophosphorylation; • positive regulation of reactive oxygen species metabolic process; • reactive oxygen species metabolic process; • negative regulation of transcription, DNA-templated; • protein kinase C signaling; • metanephric glomerular mesangial cell development; • negative regulation of phosphatidylinositol biosynthetic process; • response to wounding; • positive regulation of phosphatidylinositol 3-kinase activity; • cell chemotaxis; • positive regulation of ERK1 and ERK2 cascade; • platelet degranulation; • ضبط زيادي للتكاثر الخلوي; • positive regulation of DNA replication; • positive regulation of gene expression; • embryonic placenta development; • تأشير نظير صماوي; • monocyte chemotaxis; • positive regulation of endothelial cell proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of calcium ion import; • positive regulation of transcription, DNA-templated; • peptidyl-serine phosphorylation; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of blood vessel endothelial cell migration; • تكون الدم; • positive regulation of cell migration; • positive regulation of peptidyl-tyrosine phosphorylation; • extracellular matrix organization; • negative regulation of protein binding; • positive regulation of MAPK cascade; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of platelet activation; • phosphatidylinositol phosphorylation; • positive regulation of vascular associated smooth muscle cell migration; • positive chemotaxis; • negative regulation of vascular smooth muscle cell differentiation; • interleukin-18-mediated signaling pathway; • positive regulation of pri-miRNA transcription from RNA polymerase II promoter; • negative regulation of pri-miRNA transcription from RNA polymerase II promoter; • negative regulation of gene expression; • positive regulation of smooth muscle cell migration; • positive regulation of smooth muscle cell proliferation; • positive regulation of vascular smooth muscle cell dedifferentiation; • platelet-derived growth factor receptor signaling pathway; • positive regulation of vascular smooth muscle cell proliferation; • negative regulation of platelet-derived growth factor receptor-beta signaling pathway; • regulation of receptor activity; • positive regulation of protein kinase B signaling;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P01127
	P31240
	‏NM_002608 NM_033016، ‏NM_002608
	‏XM_006520592، ‏XM_017316502 NM_011057، ‏XM_006520592، ‏XM_017316502
	‏NP_148937 NP_002599، ‏NP_148937
	‏XP_006520655، ‏XP_030104268، ‏XP_030104269، ‏XP_030104270، ‏XP_030104271 NP_035187، ‏XP_006520655، ‏XP_030104268، ‏XP_030104269، ‏XP_030104270، ‏XP_030104271
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

PDGFB‏ (Platelet derived growth factor subunit B) هوَ بروتين يُشَفر بواسطة جين PDGFB في الإنسان.[1][2]

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

المراجع

Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670. الوسيط |CitationClass= تم تجاهله (مساعدة)
Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848. الوسيط |CitationClass= تم تجاهله (مساعدة)

قراءة متعمقة

Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185. الوسيط |CitationClass= تم تجاهله (مساعدة)

بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي

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[pmid1661670-1] Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670. الوسيط |CitationClass= تم تجاهله (مساعدة)

[pmid2991848-2] Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848. الوسيط |CitationClass= تم تجاهله (مساعدة)