Myc
Myc هو جين منظم يعمل على تشفير عامل النسخ. اكتُشفَ هذا الجين لأول مرة في شخص مُصاب بلمفوما بيركت.
MYC proto-oncogene, bHLH transcription factor | |||||||
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المعرفات | |||||||
الأسماء المستعارة | avian myelocytomatosis viral oncogene homolog, MYC, bHLHe39, transcription factor p64, myc-related translation/localization regulatory factor, v-myc myelocytomatosis viral oncogene homolog, v-myc avian myelocytomatosis viral oncogene homolog, proto-oncogene c-Myc, class E basic helix-loop-helix protein 39, myc proto-oncogene protein | ||||||
معرفات خارجية | |||||||
أورثولوج | |||||||
الأنواع | الإنسان | الفأر | |||||
أنتريه | n/a | ||||||
Ensembl | n/a | n/a | |||||
يونيبروت |
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RefSeq (مرسال ر.ن.ا.) |
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RefSeq (بروتين) |
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الموقع (UCSC | n/a | ||||||
بحث ببمد | n/a | ||||||
ويكي بيانات | |||||||
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التركيب
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
الوظيفة
يعمل علي بدء دوره الخلية منG0 حتى إكمال الدورة، كما أن لهُ دورٌ في تثبيط الجينات المسؤولة عن موت الخلايا المبرمج.
التآثرات
وجدَ أنَّ Myc يتآثر مع:
- ACTL6A[1]
- بروتين BRCA1 ومرض ألزهايمر[2][3][4][5]
- عائلة بي سي إل 2[6]
- Cyclin T1[7]
- CHD8[8]
- DNMT3A[9]
- EP400[10]
- GTF2I[11]
- HTATIP[12]
- let-7[13][14][15]
- MAPK1[6][16][17]
- MAPK8[18]
- MAX[19][20][21][22][23][24][25][26][27][28][29][30][31]
- MLH1[23]
- MYCBP2[32]
- MYCBP[33]
- N-myc[2]
- NFYB[34]
- NFYC[35]
- P73[36]
- PCAF[37]
- PFDN5[38][39]
- RuvB-like 1[1][10]
- SAP130[37]
- SMAD2[40]
- SMAD3[40]
- SMARCA4[1][19]
- SMARCB1[22]
- SUPT3H[37]
- TIAM1[41]
- TADA2L[37]
- TAF9[37]
- TFAP2A[42]
- TRRAP[1][20][21][37]
- WDR5[43]
- YY1[44] and
- ZBTB17.[45][46]
المراجع
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تم تجاهله (مساعدة)
وصلات خارجية
- myc Proto-Oncogene Proteins في المَكتبة الوَطنية الأمريكية للطب نظام فهرسة المواضيع الطبية (MeSH).
- بوابة الكيمياء الحيوية
- بوابة علم الأحياء
- بوابة علم الأحياء الخلوي والجزيئي
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