Myc

Myc هو جين منظم يعمل على تشفير عامل النسخ. اكتُشفَ هذا الجين لأول مرة في شخص مُصاب بلمفوما بيركت.

MYC proto-oncogene, bHLH transcription factor
المعرفات
الأسماء المستعارة avian myelocytomatosis viral oncogene homolog, MYC, bHLHe39, transcription factor p64, myc-related translation/localization regulatory factor, v-myc myelocytomatosis viral oncogene homolog, v-myc avian myelocytomatosis viral oncogene homolog, proto-oncogene c-Myc, class E basic helix-loop-helix protein 39, myc proto-oncogene protein
معرفات خارجية
أورثولوج
الأنواع الإنسان الفأر
أنتريه n/a
Ensembl n/a n/a
يونيبروت

n/a

n/a

RefSeq (مرسال ر.ن.ا.)

n/a

n/a

RefSeq (بروتين)

n/a

n/a

الموقع (UCSC n/a
بحث ببمد n/a
ويكي بيانات
اعرض/عدّل إنسان

التركيب

الوظيفة

يعمل علي بدء دوره الخلية منG0 حتى إكمال الدورة، كما أن لهُ دورٌ في تثبيط الجينات المسؤولة عن موت الخلايا المبرمج.

التآثرات

وجدَ أنَّ Myc يتآثر مع:

المراجع

  1. Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713. PMID 11839798. الوسيط |CitationClass= تم تجاهله (مساعدة)
  2. Li H, Lee TH, Avraham H (June 2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". The Journal of Biological Chemistry. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966. الوسيط |CitationClass= تم تجاهله (مساعدة)
  3. Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG, Rosen EM (December 2003). "BRCA1 inhibition of telomerase activity in cultured cells". Molecular and Cellular Biology. 23 (23): 8668–90. doi:10.1128/mcb.23.23.8668-8690.2003. PMC 262673. PMID 14612409. الوسيط |CitationClass= تم تجاهله (مساعدة)
  4. Zhou C, Liu J (March 2003). "Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells". Biochemical and Biophysical Research Communications. 303 (1): 130–6. doi:10.1016/s0006-291x(03)00318-8. PMID 12646176. الوسيط |CitationClass= تم تجاهله (مساعدة)
  5. Wang Q, Zhang H, Kajino K, Greene MI (October 1998). "BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells". Oncogene. 17 (15): 1939–48. doi:10.1038/sj.onc.1202403. PMID 9788437. الوسيط |CitationClass= تم تجاهله (مساعدة)
  6. Jin Z, Gao F, Flagg T, Deng X (September 2004). "Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation". The Journal of Biological Chemistry. 279 (38): 40209–19. doi:10.1074/jbc.M404056200. PMID 15210690. الوسيط |CitationClass= تم تجاهله (مساعدة)
  7. Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM (August 2003). "c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis". Oncogene. 22 (36): 5707–11. doi:10.1038/sj.onc.1206800. PMID 12944920. الوسيط |CitationClass= تم تجاهله (مساعدة)
  8. Dingar D, Kalkat M, Chan PK, Srikumar T, Bailey SD, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Penn LZ, Raught B (April 2015). "BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors". Journal of Proteomics. 118 (12): 95–111. doi:10.1016/j.jprot.2014.09.029. PMID 25452129. الوسيط |CitationClass= تم تجاهله (مساعدة)
  9. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L, Fuks F (January 2005). "Myc represses transcription through recruitment of DNA methyltransferase corepressor". The EMBO Journal. 24 (2): 336–46. doi:10.1038/sj.emboj.7600509. PMC 545804. PMID 15616584. الوسيط |CitationClass= تم تجاهله (مساعدة)
  10. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi:10.1016/s0092-8674(01)00450-0. PMID 11509179. الوسيط |CitationClass= تم تجاهله (مساعدة)
  11. Roy AL, Carruthers C, Gutjahr T, Roeder RG (September 1993). "Direct role for Myc in transcription initiation mediated by interactions with TFII-I". Nature. 365 (6444): 359–61. doi:10.1038/365359a0. PMID 8377829. الوسيط |CitationClass= تم تجاهله (مساعدة)
  12. Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM, Amati B (June 2003). "MYC recruits the TIP60 histone acetyltransferase complex to chromatin". EMBO Reports. 4 (6): 575–80. doi:10.1038/sj.embor.embor861. PMC 1319201. PMID 12776177. الوسيط |CitationClass= تم تجاهله (مساعدة)
  13. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT (January 2008). "Widespread microRNA repression by Myc contributes to tumorigenesis". Nature Genetics. 40 (1): 43–50. doi:10.1038/ng.2007.30. PMC 2628762. PMID 18066065. الوسيط |CitationClass= تم تجاهله (مساعدة)
  14. Koscianska E, Baev V, Skreka K, Oikonomaki K, Rusinov V, Tabler M, Kalantidis K (2007). "Prediction and preliminary validation of oncogene regulation by miRNAs". BMC Molecular Biology. 8: 79. doi:10.1186/1471-2199-8-79. PMC 2096627. PMID 17877811. الوسيط |CitationClass= تم تجاهله (مساعدة)
  15. Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M (May 2005). "CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells". The Journal of Biological Chemistry. 280 (20): 20086–93. doi:10.1074/jbc.M410036200. PMID 15769738. الوسيط |CitationClass= تم تجاهله (مساعدة)
  16. Gupta S, Davis RJ (October 1994). "MAP kinase binds to the NH2-terminal activation domain of c-Myc". FEBS Letters. 353 (3): 281–5. doi:10.1016/0014-5793(94)01052-8. PMID 7957875. الوسيط |CitationClass= تم تجاهله (مساعدة)
  17. Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ (July 1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7337–42. doi:10.1073/pnas.94.14.7337. PMC 23822. PMID 9207092. الوسيط |CitationClass= تم تجاهله (مساعدة)
  18. Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y (November 1999). "Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase". The Journal of Biological Chemistry. 274 (46): 32580–7. doi:10.1074/jbc.274.46.32580. PMID 10551811. الوسيط |CitationClass= تم تجاهله (مساعدة)
  19. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. الوسيط |CitationClass= تم تجاهله (مساعدة)
  20. McMahon SB, Wood MA, Cole MD (January 2000). "The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc". Molecular and Cellular Biology. 20 (2): 556–62. doi:10.1128/mcb.20.2.556-562.2000. PMC 85131. PMID 10611234. الوسيط |CitationClass= تم تجاهله (مساعدة)
  21. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (August 1998). "The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. doi:10.1016/s0092-8674(00)81479-8. PMID 9708738. الوسيط |CitationClass= تم تجاهله (مساعدة)
  22. Cheng SW, Davies KP, Yung E, Beltran RJ, Yu J, Kalpana GV (May 1999). "c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function". Nature Genetics. 22 (1): 102–5. doi:10.1038/8811. PMID 10319872. الوسيط |CitationClass= تم تجاهله (مساعدة)
  23. Mac Partlin M, Homer E, Robinson H, McCormick CJ, Crouch DH, Durant ST, Matheson EC, Hall AG, Gillespie DA, Brown R (February 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene. 22 (6): 819–25. doi:10.1038/sj.onc.1206252. PMID 12584560. الوسيط |CitationClass= تم تجاهله (مساعدة)
  24. Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–7. doi:10.1126/science.2006410. PMID 2006410. الوسيط |CitationClass= تم تجاهله (مساعدة)
  25. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP (October 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14189–94. doi:10.1073/pnas.232310199. PMC 137859. PMID 12391307. الوسيط |CitationClass= تم تجاهله (مساعدة)
  26. Billin AN, Eilers AL, Queva C, Ayer DE (December 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological Chemistry. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926. الوسيط |CitationClass= تم تجاهله (مساعدة)
  27. Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857. الوسيط |CitationClass= تم تجاهله (مساعدة)
  28. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233. الوسيط |CitationClass= تم تجاهله (مساعدة)
  29. Nair SK, Burley SK (January 2003). "X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors". Cell. 112 (2): 193–205. doi:10.1016/s0092-8674(02)01284-9. PMID 12553908. الوسيط |CitationClass= تم تجاهله (مساعدة)
  30. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (April 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. PMID 10229200. الوسيط |CitationClass= تم تجاهله (مساعدة)
  31. Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583. الوسيط |CitationClass= تم تجاهله (مساعدة)
  32. Guo Q, Xie J, Dang CV, Liu ET, Bishop JM (August 1998). "Identification of a large Myc-binding protein that contains RCC1-like repeats". Proceedings of the National Academy of Sciences of the United States of America. 95 (16): 9172–7. doi:10.1073/pnas.95.16.9172. PMC 21311. PMID 9689053. الوسيط |CitationClass= تم تجاهله (مساعدة)
  33. Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi:10.1046/j.1365-2443.1998.00206.x. PMID 9797456. الوسيط |CitationClass= تم تجاهله (مساعدة)
  34. Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (April 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". Journal of Cell Science. 114 (Pt 8): 1533–44. PMID 11282029. الوسيط |CitationClass= تم تجاهله (مساعدة)
  35. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". The Journal of Biological Chemistry. 274 (34): 24270–9. doi:10.1074/jbc.274.34.24270. PMID 10446203. الوسيط |CitationClass= تم تجاهله (مساعدة)
  36. Uramoto H, Izumi H, Ise T, Tada M, Uchiumi T, Kuwano M, Yasumoto K, Funa K, Kohno K (August 2002). "p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression". The Journal of Biological Chemistry. 277 (35): 31694–702. doi:10.1074/jbc.M200266200. PMID 12080043. الوسيط |CitationClass= تم تجاهله (مساعدة)
  37. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246. الوسيط |CitationClass= تم تجاهله (مساعدة)
  38. Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (November 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". The Journal of Biological Chemistry. 273 (45): 29794–800. doi:10.1074/jbc.273.45.29794. PMID 9792694. الوسيط |CitationClass= تم تجاهله (مساعدة)
  39. Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H (November 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". The Journal of Biological Chemistry. 276 (48): 45137–44. doi:10.1074/jbc.M106127200. PMID 11567024. الوسيط |CitationClass= تم تجاهله (مساعدة)
  40. Feng XH, Liang YY, Liang M, Zhai W, Lin X (January 2002). "Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Molecular Cell. 9 (1): 133–43. doi:10.1016/s1097-2765(01)00430-0. PMID 11804592. الوسيط |CitationClass= تم تجاهله (مساعدة)
  41. Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H (February 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry. 278 (7): 5132–40. doi:10.1074/jbc.M206733200. PMID 12446731. الوسيط |CitationClass= تم تجاهله (مساعدة)
  42. Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R, Eilers M (April 1995). "Transcriptional activation by Myc is under negative control by the transcription factor AP-2". The EMBO Journal. 14 (7): 1508–19. PMC 398238. PMID 7729426. الوسيط |CitationClass= تم تجاهله (مساعدة)
  43. Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP (May 2015). "Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC". Molecular Cell. 58 (3): 440–52. doi:10.1016/j.molcel.2015.02.028. PMC 4427524. PMID 25818646. الوسيط |CitationClass= تم تجاهله (مساعدة)
  44. Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081. الوسيط |CitationClass= تم تجاهله (مساعدة)
  45. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (April 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. الوسيط |CitationClass= تم تجاهله (مساعدة)
  46. Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (September 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026. الوسيط |CitationClass= تم تجاهله (مساعدة)

    وصلات خارجية

    • بوابة الكيمياء الحيوية
    • بوابة علم الأحياء
    • بوابة علم الأحياء الخلوي والجزيئي
    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.