HEY2

HEY2
المعرفات
الأسماء المستعارة	HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32, hes related family bHLH transcription factor with YRPW motif 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604674 MGI: MGI:1341884 HomoloGene: 22705 GeneCards: 23493
علم الوجود الجيني
الوظيفة الجزيئية	• microsatellite binding; • sequence-specific DNA binding; • ربط دي إن إي; • protein dimerization activity; • protein homodimerization activity; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • transcription factor binding; • histone deacetylase binding; • ‏GO:0000983 RNA polymerase II general transcription initiation factor activity; • RNA polymerase II activating transcription factor binding; • ‏GO:0001948 ربط بروتيني; • protein heterodimerization activity; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II regulatory region sequence-specific DNA binding; • ‏GO:0001077، ‏GO:0001212، ‏GO:0001213، ‏GO:0001211، ‏GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • ‏GO:0001106 transcription corepressor activity; • sequence-specific double-stranded DNA binding;
المكونات الخلوية	• سيتوبلازم; • transcriptional repressor complex; • Sin3 complex; • بلازم نووي; • نواة;
العمليات الحيوية	• dorsal aorta morphogenesis; • cardiac vascular smooth muscle cell development; • cochlea development; • pattern specification process; • cell fate commitment; • pulmonary valve morphogenesis; • regulation of auditory receptor cell differentiation; • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; • ضبط نسخ الدنا; • heart trabecula formation; • tricuspid valve morphogenesis; • regulation of vasculogenesis; • pulmonary artery morphogenesis; • cardiac septum morphogenesis; • negative regulation of cardiac vascular smooth muscle cell differentiation; • muscular septum morphogenesis; • ventricular septum morphogenesis; • protein-DNA complex assembly; • cardiac muscle hypertrophy; • outflow tract morphogenesis; • ascending aorta morphogenesis; • cardiac left ventricle morphogenesis; • labyrinthine layer blood vessel development; • negative regulation of transcription from RNA polymerase II promoter; • coronary vasculature morphogenesis; • smooth muscle cell differentiation; • negative regulation of gene expression; • endocardial cushion to mesenchymal transition involved in heart valve formation; • نسخ الدنا; • ventricular trabecula myocardium morphogenesis; • positive regulation of heart rate; • vasculogenesis; • نمو متعدد الخلايا; • atrial septum morphogenesis; • negative regulation of cardiac muscle cell apoptotic process; • heart development; • arterial endothelial cell differentiation; • positive regulation of cardiac muscle cell proliferation; • blood vessel development; • cardiac muscle hypertrophy in response to stress; • umbilical cord morphogenesis; • negative regulation of transcription regulatory region DNA binding; • mesenchymal cell development; • artery development; • تنظيم التعبير الجيني; • negative regulation of transcription by transcription factor localization; • negative regulation of transcription initiation from RNA polymerase II promoter; • vascular smooth muscle cell development; • anterior/posterior axis specification; • tricuspid valve formation; • negative regulation of transcription, DNA-templated; • cardiac ventricle morphogenesis; • cardiac right ventricle morphogenesis; • ventricular cardiac muscle cell development; • atrioventricular valve development; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • negative regulation of Notch signaling pathway; • cardiac epithelial to mesenchymal transition; • Notch signaling involved in heart development; • Notch signaling pathway; • positive regulation of transcription, DNA-templated; • تمايز خلوي; • regulation of neurogenesis; • aortic valve morphogenesis; • epithelial to mesenchymal transition involved in endocardial cushion formation; • positive regulation of gene expression; • negative regulation of biomineral tissue development; • نقل شاردة الكالسيوم; • circulatory system development;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9UBP5; Q5TF93
	Q9QUS4
	‏XM_017010627، ‏XM_017010628، ‏XM_017010629 NM_012259، ‏XM_017010627، ‏XM_017010628، ‏XM_017010629
	NM_013904
	‏XP_016866116، ‏XP_016866117، ‏XP_016866118 NP_036391، ‏XP_016866116، ‏XP_016866117، ‏XP_016866118; XP_011533952.1
	NP_038932
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HEY2‏ (Hes related family bHLH transcription factor with YRPW motif 2) هوَ بروتين يُشَفر بواسطة جين HEY2 في الإنسان.[1][2]

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

المراجع

Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech. Dev. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. الوسيط |CitationClass= تم تجاهله (مساعدة)
"Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2". مؤرشف من الأصل في 05 ديسمبر 2010. الوسيط |CitationClass= تم تجاهله (مساعدة)

قراءة متعمقة

Iso T, Kedes L, Hamamori Y (2003). "HES and HERP families: multiple effectors of the Notch signaling pathway". J. Cell. Physiol. 194 (3): 237–55. doi:10.1002/jcp.10208. PMID 12548545. الوسيط |CitationClass= تم تجاهله (مساعدة)
Kokubo H, Miyagawa-Tomita S, Johnson RL (2005). "Hesr, a mediator of the Notch signaling, functions in heart and vessel development". Trends Cardiovasc. Med. 15 (5): 190–4. doi:10.1016/j.tcm.2005.05.005. PMID 16165016. الوسيط |CitationClass= تم تجاهله (مساعدة)
Chin MT, Maemura K, Fukumoto S, Jain MK, Layne MD, Watanabe M, Hsieh CM, Lee ME (2000). "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system". J. Biol. Chem. 275 (9): 6381–7. doi:10.1074/jbc.275.9.6381. PMID 10692439. الوسيط |CitationClass= تم تجاهله (مساعدة)
Zhong TP, Rosenberg M, Mohideen MA, Weinstein B, Fishman MC (2000). "gridlock, an HLH gene required for assembly of the aorta in zebrafish". Science. 287 (5459): 1820–4. doi:10.1126/science.287.5459.1820. PMID 10710309. الوسيط |CitationClass= تم تجاهله (مساعدة)
Steidl C, Leimeister C, Klamt B, Maier M, Nanda I, Dixon M, Clarke R, Schmid M, Gessler M (2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics. 66 (2): 195–203. doi:10.1006/geno.2000.6200. PMID 10860664. الوسيط |CitationClass= تم تجاهله (مساعدة)
Firulli BA, Hadzic DB, McDaid JR, Firulli AB (2000). "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function". J. Biol. Chem. 275 (43): 33567–73. doi:10.1074/jbc.M005888200. PMC 2561327. PMID 10924525. الوسيط |CitationClass= تم تجاهله (مساعدة)
Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN (2000). "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13655–60. doi:10.1073/pnas.250485597. PMC 17631. PMID 11095750. الوسيط |CitationClass= تم تجاهله (مساعدة)
Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y (2001). "HERP, a new primary target of Notch regulated by ligand binding". Mol. Cell. Biol. 21 (17): 6071–9. doi:10.1128/MCB.21.17.6071-6079.2001. PMC 87324. PMID 11486044. الوسيط |CitationClass= تم تجاهله (مساعدة)
Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y (2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. doi:10.1128/MCB.21.17.6080-6089.2001. PMC 87325. PMID 11486045. الوسيط |CitationClass= تم تجاهله (مساعدة)
Takata T, Ishikawa F (2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. PMID 12535671. الوسيط |CitationClass= تم تجاهله (مساعدة)
Fischer A, Klamt B, Schumacher N, Glaeser C, Hansmann I, Fenge H, Gessler M (2004). "Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome". Mamm. Genome. 15 (9): 711–6. doi:10.1007/s00335-004-2389-x. PMID 15389319. الوسيط |CitationClass= تم تجاهله (مساعدة)
Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL (2005). "Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system". Dev. Biol. 278 (2): 301–9. doi:10.1016/j.ydbio.2004.10.025. PMID 15680351. الوسيط |CitationClass= تم تجاهله (مساعدة)
Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto E, Arai M, Kedes L, Kurabayashi M (2005). "HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box". Arterioscler. Thromb. Vasc. Biol. 25 (11): 2328–34. doi:10.1161/01.ATV.0000185829.47163.32. PMID 16151017. الوسيط |CitationClass= تم تجاهله (مساعدة)
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. الوسيط |CitationClass= تم تجاهله (مساعدة)

بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي

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[pmid10415358-1] Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech. Dev. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. الوسيط |CitationClass= تم تجاهله (مساعدة)

[entrez-2] "Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2". مؤرشف من الأصل في 05 ديسمبر 2010. الوسيط |CitationClass= تم تجاهله (مساعدة)